The Various Kratom Alkaloids and their properties

By | June 26, 2014

The most unique and perplexing part of kratom’s effects is its ability of giving varying results between different strains. The mechanism is triggered by a number of different alkaloids usually seen in the Mitragyna speciosa plant, which feature varying dosage ranges. There has been knowledge and study of some kratom alkaloids and due to lack of scientific study, there could be more alkaloids in the plant we may not have knowledge about.

The alkaloid content of the Mitragyna speciosa kratom differ in terms of geographical location, monthly growth, and leaf harvest periods, which prompted some scientific groups to conclude that there may be varying geographical diversities of the same species.

A kratom’s alkaloid composition will differ between strains which lead to varying effects. Alkaloid properties will vary between locations around Southeast Asia and will diversify on the period of leaf harvest. With this mind, scientists have worked with kratom suppliers to bring methods that would mitigate such differences leading to similar potent kratom products all year around.

Mitragyna speciosa kratomThe common aspect between all strains of kratom despite their location, harvest time, or other factors is that a majority of the alkaloid content is mitragynine. This doesn’t make mitragynine the ultimate alkaloid. It’s thought that among kratom alkaloids the most potent one is the alkaloid 7-Hydroxymitragynine, which is believed to be 30 times stronger than mitragynine and a dozen times more powerful than morphine.

The alkaloid groups responsible for depressing the nervous system are observed in lower alkaloid concentrations. Hence, larger dosages will be needed to attain the effects of such central nervous depressing alkaloid groups.

As previously indicated, kratom species from different regions will be concentrated with mitragynine. Higher sedating kratom strains like that of the red vein kratom variants will have higher Mitraphylline and 7-Hydroxymitragynine concentrations. Meanwhile, stimulating white and green strains will have denser mitragynine and lower 7-Hydroxymitragynine content.

A majority of lower strength alkaloids seem to possess a synergistic effect when mixed with today’s highly potent alkaloid groups. It is one reason why full spectrum kratom extracts offer the most enjoyable and consistent results. On the downside these extracts, also induce tolerance possibly due to the powerful effects of the mixed alkaloids.

Despite its biological makeup and centuries of use, it’s a fact that kratom is more than just a simple stimulant and opioid resembling narcotic. Most of the subordinate content found in the kratom are present in minimal yet adequate concentrations, and their synergistic role and mechanisms haven’t been fully understood as scientific study of the herb has just started.

Here are the notable alkaloids observed in a typical kratom plant:

  • Ajmalicine:

Known to be an antiaggregant, anti-adrenergic, sedative, muscle relaxant, and anti-coagulant

  • Ciliaphylline:

Known to be an analgesic

  • Corynantheidine:

Known to be an opioid antagonist

  • Corynoxeine:

Known to be a calcium channel blocker

  • Corynoxine:

Known to be a dopamine facilitating anti-locomotive

  • Epicatechin:

Known to be an antioxidant with anti-diabetic, anti-hepatic, anti-inflammatory, anti-leukemic,
anti-viral, anti-cancer, and anti-bacterial properties

  • 7-hydroxymitragynine:

Known to be an analgesic, anti-diarrheal, and an antitussive

  • Isomitraphylline:

Known to be an immunostimulant and as anti-leukemic

  • Mitragynine:

Known to be an analgesic, anti-diarrheal, anti-malarial, and a psychedelic antagonist

  • Mitraphylline:

Known to be a vasodilator, muscle relaxant, diuretic, immune stimulant, and a vasodilator

  • Paynantheine:

Known to be a smooth muscle relaxant

  • Rhynchophylline:

Known to be a vasodilator, calcium channel blocker and a hypertensive

  • Speciogynine:

Known to be a smooth muscle relaxant

  • Speciophylline:

Known to be an anti-leukemic

  • Tetrahydroalstonine:

Known to be an anti-adrenergic and a hypoglycemic.